BATF (gene)
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External IDsOMIM: 612476; MGI: 1859147; HomoloGene: 4666; GeneCards: BATF; OMA:BATF - orthologs
Basic leucine zipper transcription factor, ATF-like, also known as BATF, is a protein which in humans is encoded by the BATF gene.[5][6][7]
The protein encoded by this gene is a nuclear basic leucine zipper (bZIP) protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events.[7]
Mice without the BATF gene (BATF knockout mice) lacked a type of inflammatory immune cell (Th17) and were resistant to conditions that normally induces an autoimmune condition similar to multiple sclerosis.[8]
