1H-LSD
Pharmaceutical compound
From Wikipedia, the free encyclopedia
1H-LSD, also known as 1-hexanoyl-LSD or as SYN-L-027,[1] is an acylated derivative of lysergic acid diethylamide (LSD), with a six carbon hexanoyl chain attached to the N1 position.[2] It acts as a prodrug for LSD, and in animal studies produces drug-appropriate responding with a similar potency to short-chain homologues such as ALD-52 and 1P-LSD, in contrast to the 4 and 5 carbon homologues 1B-LSD and 1V-LSD which are several times weaker.[3]
- DE: NpSG (Industrial and scientific use only)
- UK: Under Psychoactive Substances Act
- US: Unscheduled (may be covered by the Federal Analogue Act if sold for human consumption)
- UN: Unscheduled
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| Other names | 1-Hexanoyl-LSD; SYN-L-027 |
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| Formula | C26H35N3O2 |
| Molar mass | 421.585 g·mol−1 |
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Use and effects
1H-LSD produces similar effects to LSD with a shorter metabolic half-life.[citation needed] There are no documented cases of it being used recreationally.[4]
Interactions
Chemistry
Analogues
Analogues of 1H-LSD include ALD-52 (1A-LSD), 1P-LSD, 1cP-LSD, 1DD-LSD, 1cP-AL-LAD, and 1P-ETH-LAD, among others.
Society and culture
Legal status
Canada
1H-LSD is not an explicitly nor implicitly controlled substance in Canada as of 2025.[5]
United States
1H-LSD is not an explicitly controlled substance in the United States.[6] However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.